Endocrine Abstracts

Introduction: Although thyroid nodules (TN) are less common in children than in adults, the risk of malignancy is much higher in pediatric age and therefore representing greater concern in this age group.Objective: Evaluate a cohort of pediatric patients with TN and search differences between subjects with malignant and benign TN regarding sex, age, compressive symptoms, cervical ultrasound characteristics, family history of differentiated thyroid cancer...

Introduction: Patients with primary adrenal insufficiency (PAI) require lifelong corticoids replacement and they are at risk of therapy-related osteoporosis and cardiovascular complications.Objectives: Determine the prevalence of cardiovascular risk factors, osteoporosis, and other toxicities related with corticoids treatment.Material and methods: Retrospective, descriptive study in patients with PAI follow up in our service during...

Insulinoma, a rare neuroendocrine tumor (NET), is benign in more than 90% of cases. We present a review of patients diagnosed with insulinoma at our Department.Methods: Retrospective review of clinical records of patients diagnosed with insulinoma between 2011 and 2016.Results: Six female patients were diagnosed with insulinoma (age at presentation 30–66, follow-up: 0.25–3.25 years). Episodes of sweating, palpitations, tr...

Insulin autoimmune syndrome (IAS) is a very rare cause of hypoglycaemia in western countries. One proposed mechanism is anti-insulin antibody capture of prandial insulin followed by the dissociation of insulin from anti-insulin antibody. The first objective was to study the relationship between glucose, insulin and C-peptide during a prolonged glucose load in two patients with active IAS. The second was to study the variation of these parameters between the active and the reco...

Background: Nivolumab is a monoclonal antibody specific for human PD-1 (programmed cell death protein-1), a checkpoint molecule highly expressed in several cancers. Nivolumab is an immunotherapeutic strategy for human cancer, but it can interfere with endocrine system.Case reports: We report four cases regarding nivolumab-associated endocrinopathies: (i) Male, 55-year-old, with previous normal cortisol and adrenocorticotropic hormone (ACTH) levels, treat...

Introduction: During childhood and puberty, growth hormone(GH) is essential for linear growth. Consequently, children with isolated GH deficiency(GHD) must receive replacement therapy. GH has also important metabolic actions. GHD in adults is associated with altered body composition. However, long-term consequences of GH treatment in adults is not sufficiently known.Objective: To evaluate GH treatment during pediatric age in patients with isolated GHD.</...

Thyroid nodules are a common clinical finding, with an estimated prevalence of palpable thyroid nodules to be approximately 5% in women and 1% in men. The clinical importance of thyroid nodules rests with the need to exclude thyroid cancer. The prevalence of malignancy reported for palpable thyroid lesions ranges from 5.0% to 6.5%. Patients with benign thyroid nodules are unlikely to suffer morbidity or mortality due to thyroid cancer. A 53 aged man presented with a 20-year hi...

Background: Hypomagnesemia is common in patients with diabetes; possibly due to higher renal magnesium excretion in those patients. Hypomagnesemia seems to correlate with poor glycaemic control. The relationship between urinary magnesium (UMg) and glycaemic control is not known. We aimed to study the association between UMg and glycaemic control in a type 1 diabetes (T1D) pediatric population.Methods: Study of a pediatric population with T1D attending th...

Introduction: The diagnosis of Cushing’s syndrome is often challenging considering that none of the used laboratory tests has an ideal diagnostic accuracy. The complexity of the diagnosis increases in cyclic disorder, which is characterized by repeated episodes of cortisol excess followed by periods of normal cortisol secretion.Case report: A 32-year-old woman with history of arterial hypertension and obesity presented with weight gain, hirsutism, a...

Introduction: Hyperglycemia (irrespective of the presence of diabetes) has been associated with worse outcomes in hospitalized patients with a variety of diseases, namely critical illness. It is been recently proposed that a relative hyperglycemia – Stress Hyperglycemia Ratio (SHR) – might be even better associated with disease outcomes. We studied how SHR correlated with various morbidity parameters in hospitalized patients due to acute pyelonephritis.<p class="...